Dermal exposure to chemicals - evaluation of skin barrier damage
نویسندگان
چکیده
منابع مشابه
Dermal exposure to chemicals in the workplace: just how important is skin absorption?
Correspondence to: Dr S Semple, Department of Environmental & Occupational Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK; [email protected] _________________________ T he study of occupational and environmental exposure to chemicals has traditionally focussed on the quantity of dust, aerosol, or vapour inhaled. This has been driven by the high historic prevalence of...
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There are a large number of workers in the United States, spanning a variety of occupational industries and sectors, who are potentially exposed to chemicals that can be absorbed through the skin. Occupational skin exposures can result in numerous diseases that can adversely affect an individual's health and capacity to perform at work. In general, there are three types of chemical-skin interac...
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IMPORTANCE Solar UV irradiation causes photoaging, characterized by fragmentation and reduced production of type I collagen fibrils that provide strength to skin. Exposure to UV-B irradiation (280-320 nm) causes these changes by inducing matrix metalloproteinase 1 and suppressing type I collagen synthesis. The role of UV-A irradiation (320-400 nm) in promoting similar molecular alterations is l...
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The prediction of side-effects is a key issue in the REACH initiative on chemicals in the preclinical testing of drugs. The dermal irritation and skin sensitization toxicity potential of a new molecule, vitacoxib, were invested in rabbits and guinea pigs in compliance with the Organization for Economic Cooperation and Development guideline. To assess dermal irritation, rabbits were dermally att...
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BACKGROUND Literature data indicate that terrestrial life stages of amphibians may be more sensitive to xenobiotics than birds or mammals. It is hypothesized that dermal exposure could potentially be a significant route of exposure for amphibians, as there is evidence that their skin is more permeable than the skin of other vertebrate species. Thus, higher amounts of xenobiotics might enter sys...
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ژورنال
عنوان ژورنال: Acta Chimica Slovaca
سال: 2012
ISSN: 1337-978X
DOI: 10.2478/v10188-012-0011-5